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Bioinformatics Manager

The Bioinformatics Manager contributes to toxicological risk assessments of flavor substances, tobacco ingredients, NTM ingredients, packaging ingredients, and other substances used in the manufacture of JTI products by developing and deploying state of the art in silico toxicological tools including scientific data handling approaches. In this context, the incumbent is responsible for the development of methods and software tools for understanding biological data, which are aligned with user requirements from SRA business units. The incumbent will ensure the scientific integrity of JTIs in silico toxicological tools while testing and validating the tools to verify the correctness of scientific data handling, search engines, workflows, and predictive models. The incumbent will contribute to the  SRA digitalization initiative interacting with end users and suppliers, as necessary.
The incumbent supports the training activities of other relevant internal stakeholders and actively contributes to the external communication for example in publications, scientific conferences or in meetings with their expert network. The incumbent will provide project management support to aid the Toxicology team while promoting Agile ways of working for incorporation into procedures and processes.

Position:

• Risk assessment and in silico Data handling and analysis

Contribute to toxicological risk assessments of flavor substances, tobacco ingredients, NTM ingredients, packaging ingredients, and other substances used in the manufacture of JTI products to ensure the scientific defensibility of products worldwide.

Identify and process relevant safety datasets (internal and external/new and existing) and scientific resources for computational predictive methods to fill data gaps and employ evidence toolkits. 

• In Silico Tools and data handling - Development

Collaborate with Toxicologists, Researchers, and Data Scientists to conceive computational analysis strategies including customized data, tools, and system integration pipelines to support prediction of endpoints and combination of evidence to aid toxicological risk assessments. Specific applications can be but are not limited to -omics, pharmacokinetics, in vitro and /or in vivo safety data, Adverse Outcome Pathway (AOP) analysis, molecular data integration, Integrated Approaches to Testing and Assessment (IATA) tools to fill the gap between evolving scientific research and regulatory assessment challenges. Affinity with Findable, Accessible, Interoperable, and Reusable (FAIR) principles. Ensure appropriate documentation, continuous improvement, redundancy protocols, and further development of existing tools to maintain state of the art in silico toxicological tools within JTI.

• SRA (Scientific Regulatory Affairs) Digitalization

Contribute to developing and aligning a digitalization agenda to reinforce the SRA digital landscape, aiming to integrate new and existing scientific data and computational methods to support pipeline programs and platform technology to ease end-user adoption. 
Contribute in the transition to NGRA, including handling and integration of NAMs data, ensuring proper documentation, and playing a key role in leveraging applied computational literacy within the team.

• Product Compliance and External Engagement

Support toxicology team members to meet regulatory requirements and submission deadlines with the provision of data for use in toxicological prediction tools, but not limited to, cheminformatics, exposure modeling, bioinformatics, and advanced database searches. Communicate results efficiently and effectively ensuring appropriate documentation and filing of data and/or reports.

Represent JTI at meetings with external experts in the area of bioinformatics. Actively contribute to publications and conferences. Closely monitor competitor activities and support the development of relevant company positions.

• Project Management

Support toxicology team members with project management, while promoting Agile ways of working for incorporation into procedures and processes.

Requirements: 

• University degree in Life Science, Chemistry, Toxicology, Cheminformatics, Bioinformatics, or in a related field. Degree or PhD in toxicology as well as ERT (European Registered Toxicologist) or DABT (Diplomate of the American Board of Toxicology) certification is a plus
• 3-5+ years of relevant experience dealing with chemical structures and chemical data in academia or industry
• Experience with various computational toxicology approaches including, but not limited to predictive QSAR models for physical/chemical properties and human health toxicological endpoints, such as EPI Suite or the OECD QSAR Toolbox
• Knowledge of emerging toxicological and risk assessment technologies, applied computational methods, exposure modeling, alternative in vitro exposure systems, is a plus
• Expertise in data handling methods related to toxicological risk assessment in a regulatory context. Experience with data-driven research and tools in a regulated environment
• High degree of flexibility, project management, agility, and motivation as well as good analytical skills and a problem-solving mindset
• Strong interpersonal skills with the ability to work independently and cross-functionally in expert teams to support Next Generation Risk Assessment (NGRA)
• Experience in developing and delivering training is preferable
• Excellent English communication skills (both written and oral), further language skills would be an additional asset

Are you ready to join us? Build your success story at JTI. Apply now!

Next Steps:

After applying, if selected, please anticipate the following within 1-3 weeks of the job posting closure: Phone screening with TA > Assessment tests > Interviews > Offer. Each step is eliminatory and may vary by role type.

At JTI, we strive to create a diverse and inclusive work environment. As an equal-opportunity employer, we welcome applicants from all backgrounds. We are committed to providing reasonable adjustments to applicants with special needs. If you require any accommodations, please let the Talent Advisor know during the selection process.